Treatment of Advanced Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers

For information about the treatments listed below, see the Treatment Option Overview section.

Treatment of advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include:

• Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:
  • Intravenous chemotherapy.
  • Intraperitoneal chemotherapy.
  • Chemotherapy and targeted therapy (bevacizumab).
  • Chemotherapy and targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor.
• Chemotherapy and targeted therapy followed by surgery (possibly followed by intraperitoneal chemotherapy).
• Chemotherapy and hyperthermic peritoneal chemotherapy (HIPEC) followed by surgery.
• Chemotherapy alone for patients who cannot have surgery.
• Targeted therapy with a PARP inhibitor (olaparib, rucaparib, niraparib).

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.